THE GRILLO LAB
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    • Tony Grillo
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  • Home
  • Research
  • Publications
  • People
    • Tony Grillo
    • Current Members
  • News
  • Opportunities
  • Twitter
Welcome to the Grillo Lab!

Elucidating the Molecular Mechanisms of
​Mitochondrial Dysfunction in Disease

We are a vibrant interdisciplinary research group located at the rapidly growing University of Cincinnati. Our research explores the interface between biochemistry, metabolic physiology, and medicine. We harness the power of small molecules to better understand the mechanistic underpinnings of age-progressive and genetic neurometabolic diseases that are caused by mitochondrial dysfunctions. In this vein, we are especially determined to ask whether defects in mitochondrial energy production, metabolism, or biogenesis elicit micronutrient dyshomeostasis to cause neuroinflammation and brain degeneration in human disease.
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Latest News

The Grillo Lab publishes their work on iron accumulation in eLife!
March 21, 2023
     

The Grillo Lab in collaboration with the Kaeberlein Lab discovered that genetic deficiencies of mitochondrial Complex I induce iron overload, and iron restriction reduces neuroinflammation, neurodegenerative phenotypes, and extends lifespan. This work has important implications into the pathogenesis of Parkinson's disease and other diseases that result from neurodegeneration with brain iron accumulation.
Alaa, Sushila, and Swankita Join the Grillo Lab
January 5, 2023
     

Our first graduate students (Alaa, Swankita, and Sushila) join the lab! We are absolutely thrilled for you to begin your graduate research unraveling the influence of mitochondrial dysfunctions in human diseases. Can't wait to see the exciting discoveries you will make. Welcome!
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Dr. Grillo Joins the University of Cincinnati!
July 15, 2022
     

The Grillo Lab launched July 2022 with Tony Grillo joining the Department of Chemistry (Biochemistry Division). We are actively recruiting enthusiastic postdoctorate, graduate, and undergraduate candidates to join our vibrant team! Contact Dr. Grillo with relevant materials to apply.
Follow @GrilloAnthonyS